Wow! My good friend Minghao, in collaboration with Elçin Ünal at the University of California, Berkeley, has published not one, but two articles in eLife! Read more below.
Our groups elucidated the transcriptional interference mechanism from a 5' extended long undecoded NDC80 transcript isoform upon its own mRNA. This effectively promotes dynamic changes in gene expression during cell differentiation.
Our labs demonstrated how transcriptional and translational inhibitory mechanisms are integrated during meiosis to temporally restrict kinetochore function. The 5' extended long undecoded NDC80 transcript isoform carries the canonical mRNA sequence, but directly causes gene repression instead.